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Hotel in Rome near the Vatican, in the heart of the Prati district

LOCATION

Hotel in Rome near the Vatican, in the heart of the Prati district

Hotel Twenty One is located at 23 Via Cola di Rienzo, one of Rome’s most elegant streets, in the Prati district.
The location is truly strategic: the hotel is halfway between the Vatican and the Spanish Steps, just a few minutes’ walk from Castel Sant’Angelo and Piazza del Popolo.

Grazie alla vicinanza con la fermata Lepanto della linea A della metropolitana, puoi raggiungere in poco tempo tutti i principali luoghi di interesse della città: Colosseo, Fori Imperiali, Stazione Termini, oltre alle vie dello shopping come Via del Corso, Via Condotti e Via del Babuino.

Whether you’re in Rome for a weekend, a longer holiday or a business trip, our location will allow you to get around quickly and easily, returning to the hotel with complete peace of mind.

Rome Vatican Hotel: what you can reach on foot from Hotel Twenty One

Choosing a hotel in Rome near the Vatican means being able to enjoy the city without always having to rely on public transport. From Hotel Twenty One, you can easily walk to:

Shopping streets in Rome

Shopping streets

Via Cola di Rienzo, Via Condotti, Via del Corso, Via del Babuino, Via dei Coronari: with boutiques, major brands and historic shops, you’ll be spoilt for choice.

Piazza di Spagna and Trinità dei Monti

Piazza di Spagna and Trinità dei Monti

reachable on foot or with just a few metro stops from the nearby Lepanto station.

Piazza del Popolo and Villa Borghese

Piazza del Popolo and Villa Borghese

about ten minutes away, ideal for starting your strolls towards the historic centre.

Castel Sant’Angelo

Castel Sant’Angelo

about 10–15 minutes away, with a pleasant walk towards the River Tiber.

St Peter’s Basilica and Vatican City

St Peter’s Basilica and Vatican City

about a 15-minute walk, via Via Cola di Rienzo and Via Crescenzio.

How to get to Hotel Twenty One

By train

From Termini Station

  • Take metro line A towards Battistini or Cornelia.

  • Get off at Lepanto station.
    From there, Hotel Twenty One is about 300 metres away: just a few minutes’ walk along the elegant streets of the Prati district.
    Dalla Stazione Termini

  • From there, Hotel Twenty One is about 300 metres away: just a few minutes’ walk along the elegant streets of the Prati district.

From Ostiense Station

  • When exiting, you can take bus line 30 direction Clodio.

  • Get off at Piazza Cavour stop.

  • From Piazza Cavour, the hotel is about 350 metres away: it’s a short walk to Via Cola di Rienzo.

(If you’re arriving from other stations such as Tiburtina, simply take the subway to Termini and follow the directions above.)

By plane

From Rome Fiumicino Airport (FCO – Leonardo da Vinci)

  • Take the Leonardo Express train to Termini Station: it’s a direct service, it takes about 32 minutes and runs every 15 minutes.

  • From Termini, continue on Metro A line towards Battistini/Cornelia and get off at Lepanto.

  • Walk a few minutes and you’ll reach the hotel, following the signs for Via Cola di Rienzo.

Alternatively, you can use one of the authorised shuttle services or taxis that run directly from the airport to the centre of Rome.

From Rome Ciampino Airport (CIA)

  • Take the bus to the Anagnina terminus (Metro Line A).

  • From Anagnina, take the Metro A towards Battistini/Cornelia and get off at Lepanto.

  • From there, the hotel is about a 5-minute walk away.

By car

If you are arriving by car, Rome is connected to the main Italian motorways via the Grande Raccordo Anulare (GRA):

  • From the north (A1 motorway from Florence)

    • Exit at Roma Nord and continue towards the GRA, following the signs for the city centre.
      Take the exits towards Via Salaria / Foro Italico / San Pietro and head towards the Prati district.
      From the south (A1 motorway from Naples)
      Exit at Roma Sud and join the GRA.
      Follow the signs for Via Aurelia / San Pietro, then continue towards the Vatican Walls and the Prati district.
      Once in the area, follow the signs for Via Cola di Rienzo 23 – Rome.
      Public car parks and private pay-and-display car parks are available near the hotel.

    • Take the exits towards Via Salaria / Foro Italico / San Pietro and head towards the Prati district.

  • From the south (A1 motorway from Naples)

    • Exit at Roma Sud and join the GRA.

    • Follow the signs for Via Aurelia / San Pietro, then continue towards the Vatican Walls and the Prati district.

Once in the area, follow the signs for Via Cola di Rienzo 23 – Rome.
Public car parks and private pay-and-display car parks are available near the hotel.

GPS coordinates

To set your sat-nav correctly, you can use these GPS coordinates:

  • Latitude: 41.908954 N

  • Longitude: 12.469097 E

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