HOTEL

Hotel Twenty One: in the heart of Rome, in the Prati district

A 4-star hotel with a modern design on Via Cola di Rienzo, one of Rome’s most elegant streets. Located between the Vatican, Piazza del Popolo and the city centre, with the Lepanto metro station just a few minutes’ walk away.

In the Prati district, halfway between the Vatican and the historic center

Hotel Twenty One is located at 23 Via Cola di Rienzo, right in the heart of the Prati district, one of Rome’s most elegant and lively neighbourhoods. From here, you can walk to the Vatican, Castel Sant’Angelo and Piazza del Popolo, whilst a few metro stops will quickly take you to all other parts of the city.
The location is ideal for both holidaymakers and business travellers: shops, restaurants, offices and public transport links are all just a short walk from the hotel. The Lepanto stop on Line A is about a 5-minute walk away and connects directly to the Spanish Steps, Termini Station and other key points in the city.
Inside, you’ll find contemporary design and 4-star amenities: modern rooms, free Wi-Fi, a buffet breakfast, a 24-hour reception and an on-site restaurant. Everything you need to experience Rome in comfort and relaxation.
A 4-star hotel with modern rooms, stylish interiors and amenities designed for couples, families or business travellers in the centre of Rome.

The location is ideal for both holidaymakers and business travellers: shops, restaurants, offices and public transport links are all just a short walk from the hotel. The Lepanto stop on Line A is about a 5-minute walk away and connects directly to the Spanish Steps, Termini Station and other key points in the city.

Inside, you’ll find contemporary design and 4-star amenities: modern rooms, free Wi-Fi, a buffet breakfast, a 24-hour reception and an on-site restaurant. Everything you need to experience Rome in comfort and relaxation.

Hotel

A 4-star hotel with modern rooms, stylish interiors and amenities designed for couples, families or business travellers in the centre of Rome.
Ingresso | Hotel 4 stelle Roma Centro

Prati district

One of Rome’s most elegant neighbourhoods: shopping streets such as Via Cola di Rienzo, restaurants, bars and quick connections to the rest of the city.
Shopping streets in Rome

Vatican & the historic centre

St Peter’s Basilica, the Vatican Museums, Castel Sant’Angelo and Piazza del Popolo are just a few minutes’ walk from the hotel, with no need for transport.
St Peter’s Basilica and Vatican City
A joyful family portrait with parents kissing their baby outdoors on a sunny day.
Our concept of hospitality in Rome

Why choose a 4-star hotel in Rome’s Prati district

We chose the Prati district because it combines a residential feel with an international spirit: quiet, elegant and safe, yet close to the city’s iconic landmarks. Staying at Hotel Twenty One means having Rome at your doorstep, without compromising on comfort.

  • Multilingual and helpful staff, ready to assist you before and during your stay.
  • Services for business travellers: a strategic location, free Wi-Fi, and quick connections to the city centre and stations.
  • Solutions for families and groups, with connecting rooms and spacious triple rooms.
  • A sweet and savoury buffet breakfast and an on-site restaurant for those who prefer to stay in the area after a day exploring Rome.
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